Creating the Ideal Microcosm for Rapid Incorporation of Bioengineered Alternative Tissues Using An Advanced Hydrogel Impregnated Gauze Dressing: A Case Series (September 2008)
by Jonathan Moore, DPM, MS.
Abstract: The purpose of this article is to demonstrate the effectiveness of a novel hydrogel impregnated gauze dressing in creating the ideal microcosm around a bioengineered alternative tissue to prevent tissue dehydration and cell death, accelerate angiogenesis, prevent infection and facilitate the interaction of growth factors with the target cells. Using the BRAIN principles along with this hydrogel impregnated gauze dressing in 50 diabetic patients with neuropathic foot ulcerations (including the six cases presented herein) resulted in substantially improved incorporation rates, increased frequency of wound closure, decreased time to achieve wound closure and a reduction in overall costs. Based on a log transformation the typical healing time is 17.8 days with a 95% confidence interval of 15.6 days to 20.2 days.
The BRAIN Principle: Managing Wounds After Application of Bioengineered Alternative Tissues to Maximize Incorporation and Wound Healing (May 2008)
by Jonathan Moore, DPM, MS.
Abstract: The efficacy of bioengineered alternative tissue (BAT) for lower extremity ulcers (diabetic and non-diabetic) is well described in the literature. What is not present in the literature is a concise description of how to manage these fragile biological tissues after application. This paper introduces the BRAIN principle for adjuvant management of wounds after application of BATs. Based on the experience of the author, utilizing the BRAIN principles have not only demonstrated improved BAT incorporation rates, it also increased the rate of wound closure.
AmeriGel Wound Dressing, the actual finished product was tested against
MRSA/VRE. Measurements were taken at 1, 6, 12 and 24 hour periods.
Clinical Evaluation (May 1998)
100% of stage I wounds were healed with no sequale, 88% of stage II
wounds were healed in an average of 46 days, 62% of stage III wounds were healed in
an average of 54 days and 16% of stage IV wounds were healed in an average
of 52 days. All wounds not healed had shown significant improvement and
continued healing progress at study's end.
Clinical Trial (September 1996)
Excellent results were demonstrated using AmeriGel Wound Dressing to
enhance granulation tissue formation, epithelialization and natural
debridement. AmeriGel Wound Dressing offers a cost-effective and efficacious
treatment option for wound care patients.
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